Retinoid X receptor beta (RXRB) expression in Sertoli cells controls cholesterol homeostasis and spermiation
نویسندگان
چکیده
منابع مشابه
Ligand-dependent contribution of RXRbeta to cholesterol homeostasis in Sertoli cells.
We show that mice expressing retinoid X receptor beta (RXRbeta) impaired in its transcriptional activation function AF-2 (Rxrb(af20) mutation) do not display the spermatid release defects observed in RXRbeta-null mutants, indicating that the role of RXRbeta in spermatid release is ligand-independent. In contrast, like RXRbeta-null mutants, Rxrb(af20) mice accumulate cholesteryl esters in Sertol...
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ژورنال
عنوان ژورنال: REPRODUCTION
سال: 2008
ISSN: 1470-1626,1741-7899
DOI: 10.1530/rep-08-0235